Presented by Professor Nicholas King, M.B. Ch.B., Ph.D., FRCPA (Hon) Professor and Head of Immunopathology, Discipline of Pathology, School of Medical Sciences USYD.
Once infected by virus, nerve cells of the brain will attract large numbers of white blood cells to clear the infection. Among these, a primitive group known as monocytes, newly minted by the bone marrow, causes inflammation that amplifies the immune response.
However, this behaviour can also cause lethal damage. In a novel therapeutic strategy, we have used immune modifying nanoparticles to modulate monocyte migration and function, to reduce inflammation, increase healing and enable survival, not just in viral infection of the brain, but in a range of other diseases in which inflammation is excessive.
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